2023-04-13

This is PMAS's COMMONS Lab daily Open Notebook.

Today is 2023.04.13

Todo today

Have a look at the COMMONS research discussion forum

- https://github.com/orgs/commons-research/discussions

Doing

Metabolite annotation Audrey and Stephanie

Annotation with https://github.com/mandelbrot-project/met_annot_enhancer

https://github.com/digital-botanical-gardens-initiative/emi_anacardiaceae/tree/main

Working on the emi_batch_00001 (Anacardiaceae) we found two interesting clusters in Pseudospondias extracts

https://pubchem.ncbi.nlm.nih.gov/compound/21581584 Ohchinolide B derivatives possibly.

Melia azedarach

https://academic.oup.com/femsle/article/120/3/267/520869

Paused

Done

Notes

Mid Thesis presentation Audrey le Cabbec

worked on insects metabolites in Rennes (ynsect)
worked with P Coulerie in New Caledonia

ICOA

Analytical, Affinity and Bioactive Strategies Cosmetic valley (Tours, Blois, Rouen) Orlean area of high horticultural prod

Eclipta alba

Culture of non native plants (Eclipta alba)

Presence of coumestan

5 enzymatic test (COX, elastase, ROS etc.)

Q : why such difference in the raw extracts conc used for testing ? Q : can you explain the heatmap again ? Q : stats significative diff Q : how did you annotate the compounds ? Which software ? Which DB ?

C forskohlii

Coleus forskohlii

[forskolin](https://en.wikipedia.org/wiki/Forskolin "Forskolin (coleonol) is a labdane diterpene produced by the plant Coleus barbatus (Blue Spur Flower). Other names include pashanabhedi, Indian coleus, makandi, HL-362, mao hou qiao rui hua. As with other members of the large diterpene class of plant metabolites, forskolin is derived from geranylgeranyl pyrophosphate (GGPP). Forskolin contains some unique functional elements, including the presence of a tetrahydropyran-derived heterocyclic ring. Forskolin is commonly used in laboratory research to increase levels of

which gave the name to the plant ?

How do you quantify forskolin iteratively ?